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ASTROPHYSICSASTROPHYSICS: Guiding the Gravity Wave SearchDavid VossGeneral relativity predicts that when massive objects crash into each other, they should emit ripples in the spacetime fabric called gravitational waves. Detection of these waves is an eagerly pursued but as yet elusive goal. The merger of binary black holes is one example of a powerful event that has been well studied theoretically in the hopes of identifying a clear gravitational wave signature. Supernovae and collapsing stars may also provide strong gravitational wave signals and thus an enlarged set of targets for detection. Dimmelmeier et al. performed computer simulations of fusion-burning stars progressing toward their golden years as nonburning neutron stars. The authors paid special attention to the particularly strong gravitational wave burst expected just after collapse, as the in-falling material slams against the hard iron core of the dying star. Exploring a wide range of parameters, they found a clear set of waveform templates that should expedite the search for gravitational waves. -- DV Phys. Rev. Lett. 98, 251101 (2007). When Galaxies Collide
BOY SCOUT SLOGAN: "BE PREPAIRED""The world is a dangerous place to live, not because of the people who are evil, but because of the people who don't do anything about it." - Albert Einstein
Threat to world peace: The possibility of a US attack on Iran
Excerpts of presentation, Vancouver 9/11 Truth Conference
By Prof. Peter Dale Scott
"I have been speaking in public for 60 years, but this is perhaps the most important topic I have ever spoken about." "I want to talk about the threat to world peace, and the possibility of a US attack, possibly a nuclear attack, on Iran." http://www.informationclearinghouse.info/article17926.htm BIOCHEMISTRYBIOCHEMISTRY: Bacterial Drug DesignGilbert ChinThe most effective weapons for fighting bacterial infections are those that bacteria use against each other. One tactic for combating the spread of drug-resistant strains is to use multiple drugs, such as the combination of dalfopristin (a type A streptogramin) and quinupristin (a type B streptogramin). The former blocks an early step in ribosomal protein synthesis, whereas the latter blocks a late step. Korczynska et al. describe the crystal structure of virginiamycin B lyase (Vgb) in complex with quinupristin (fortuitously, a chock of dalfopristin immobilizes two Vgb molecules in the crystal, but this interaction is without an in vivo correlate). Vgb inactivates the cyclic peptide antibiotic by catalyzing a linearization, and structure-based mutagenesis supports the mechanistic proposal that ring opening occurs not via hydrolysis of an ester but by means of a C-O lyase reaction. The detailed view of quinupristin binding to Vgb is consistent with its versatility in detoxifying natural and semisynthetic type B streptogramins--the known modifications all point into the solvent and away from the active site. A comparison of this complex with that of quinupristin bound to the 50S ribosomal subunit may guide design efforts aimed at reducing its affinity for Vgb without lessening its ardor for the ribosome. -- GJC Proc. Natl. Acad. Sci. U.S.A. 104, 10388 (2007). |
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